Obliterans With Organizing Pneumonia: A Possible Misdiagnosis of Lung Graft-Versus-Host Disease in Posttransplant Patients With COVID-19

Obliterans with organizing pneumonia (BOOP) is characterized by the presence of fibroblast proliferation within the lumen of the ducts and alveolar spaces, by the projection of inflammatory polyps into the lumen of the respiratory and terminal bronchioles, and by interstitial pneumonitis by mononucl...

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Published in:Experimental and clinical transplantation 2021-04, Vol.19 (4), p.393-395
Main Authors: Duarte, Fernando Barroso, Lemes, Romélia Pinheiro Gonçalves, Barroso, Karine Sampaio Nunes, Vasconcelos, João Paulo, Pitombeira, Beatriz Stela Gomes de Souza, Gurgel, Lívia Andrade, Viana, Thaísa Marjore Menezes, Duarte, Beatrice Araújo, Duarte, Isabella Araujo, Moura, Anna Thawanny Gadelha
Format: Article
Language:English
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Summary:Obliterans with organizing pneumonia (BOOP) is characterized by the presence of fibroblast proliferation within the lumen of the ducts and alveolar spaces, by the projection of inflammatory polyps into the lumen of the respiratory and terminal bronchioles, and by interstitial pneumonitis by mononuclear cells. Obliterans with organizing pneumonia can be idiopathic or secondary and is also reported in the context of chronic graft-versus-host disease (cGVHD) shown after allogeneic hematopoietic stem cell transplant (HSCT). The frequency of BOOP has been shown to vary from 3% to 6% in allogeneic HSCT recipients1,2 and has been shown to be associated with several risk factors, such as cGVHD and infectious respiratory viruses.
ISSN:1304-0855
2146-8427
DOI:10.6002/ect.2020.0360