Loading…
Frequency of the original kidney disease and its effect on the outcome of kidney transplant in the urology-nephrology center Mansoura University
Objectives: Renal allograft function and graft survival depends on many factors, including the source of the graft, immunologic matching between donor and recipient, incidence of acute rejection, and recurrence of the original kidney disease. This work aimed to evaluate the effects of the original k...
Saved in:
Published in: | Experimental and clinical transplantation 2016-04, Vol.14 (2), p.157-165 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | |
container_end_page | 165 |
container_issue | 2 |
container_start_page | 157 |
container_title | Experimental and clinical transplantation |
container_volume | 14 |
creator | Shokeir,Ahmed A Mashaly,Mohamed Elsayed Ismail,Mabrouk I Lotfy,Esam E Donia,Ahmed F Wafa,Ihab W Foda,Mohamed A Denewar,Ahmed Abdelfattah Abbas,Mohamed Hamed |
description | Objectives: Renal allograft function and graft survival depends on many factors, including the source of the graft, immunologic matching between donor and recipient, incidence of acute rejection, and recurrence of the original kidney disease. This work aimed to evaluate the effects of the original kidney disease on patient and graft survival.
Materials and Methods: This was a retrospective, single-center study that included 2189 kidney transplant recipients who were transplanted at The Urology and Nephrology Centre, Mansoura University, between 1976 and 2010. Of 2189 recipients, 1350 patients with unknown original kidney disease were excluded, with the remaining 839 patients divided into 4 groups according to their original kidney disease.
Results: We found pretransplant dialysis and blood transfusion to be statistically significant among the 4 groups. Regarding induction immunosuppressive therapy, a statistical significance was found between the 4 groups regarding the presence and type of induction therapy, with no statistical significance regarding the type of maintenance immunosuppression. There was no statistical significance between the 4 groups regarding the incidence of acute and chronic rejection. We also found recurrence of original kidney disease to be statistically significant in the 4 groups, particularly in the group that included patients with glomerular disease, where the highest rate of recurrence was reported in patients with focal segmental glomerulosclerosis and membranoproliferative glomerulonephritis, and patient and graft survival was also statistically significant.
Conclusions: The original kidney disease has an effect on renal allograft function and graft and patient survival. |
doi_str_mv | 10.6002/ect.2015.0200 |
format | article |
fullrecord | <record><control><sourceid>idealonline</sourceid><recordid>TN_cdi_idealonline_journals_IDEAL_52994</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>IDEAL_52994</sourcerecordid><originalsourceid>FETCH-LOGICAL-i243t-4ae8cc1bac35c1fe1448b5df203acf43d9268400a136310ddec7c0416721f62b3</originalsourceid><addsrcrecordid>eNotjztPAzEQhC0EElFISe-O6sL6cY-UUUggUhANqSOfvU4Mhx3OPqT7F_xkDl2qmeKb2R1C7hnMCwD-iDrNObB8Dhzgikw4k0VWSV5ekwkTIDOo8vyWzGJ0NUhZllwW1YT8blr87tDrngZL0wlpaN3RedXQT2c89tS4iCoiVd5QlyJFa4dbNPiR7pIOX_gfvvCpVT6eG-UTdSPTtaEJxz7zeD6Nlmr0CVv6OqChaxXde_eDbXSpvyM3VjURZxedkv1m_b56yXZvz9vVcpc5LkXKpMJKa1YrLXLNLDIpqzo3loNQ2kphFryoJIBiohAMjEFdapCsKDmzBa_FlDyMvc6gaoJvnMfDx_DMMD0etk_r5e6Q88VCij9qE2wm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Frequency of the original kidney disease and its effect on the outcome of kidney transplant in the urology-nephrology center Mansoura University</title><source>Freely Accessible Science Journals - check A-Z of ejournals</source><creator>Shokeir,Ahmed A ; Mashaly,Mohamed Elsayed ; Ismail,Mabrouk I ; Lotfy,Esam E ; Donia,Ahmed F ; Wafa,Ihab W ; Foda,Mohamed A ; Denewar,Ahmed Abdelfattah ; Abbas,Mohamed Hamed</creator><contributor>Haberal,Mehmet</contributor><creatorcontrib>Shokeir,Ahmed A ; Mashaly,Mohamed Elsayed ; Ismail,Mabrouk I ; Lotfy,Esam E ; Donia,Ahmed F ; Wafa,Ihab W ; Foda,Mohamed A ; Denewar,Ahmed Abdelfattah ; Abbas,Mohamed Hamed ; Haberal,Mehmet</creatorcontrib><description>Objectives: Renal allograft function and graft survival depends on many factors, including the source of the graft, immunologic matching between donor and recipient, incidence of acute rejection, and recurrence of the original kidney disease. This work aimed to evaluate the effects of the original kidney disease on patient and graft survival.
Materials and Methods: This was a retrospective, single-center study that included 2189 kidney transplant recipients who were transplanted at The Urology and Nephrology Centre, Mansoura University, between 1976 and 2010. Of 2189 recipients, 1350 patients with unknown original kidney disease were excluded, with the remaining 839 patients divided into 4 groups according to their original kidney disease.
Results: We found pretransplant dialysis and blood transfusion to be statistically significant among the 4 groups. Regarding induction immunosuppressive therapy, a statistical significance was found between the 4 groups regarding the presence and type of induction therapy, with no statistical significance regarding the type of maintenance immunosuppression. There was no statistical significance between the 4 groups regarding the incidence of acute and chronic rejection. We also found recurrence of original kidney disease to be statistically significant in the 4 groups, particularly in the group that included patients with glomerular disease, where the highest rate of recurrence was reported in patients with focal segmental glomerulosclerosis and membranoproliferative glomerulonephritis, and patient and graft survival was also statistically significant.
Conclusions: The original kidney disease has an effect on renal allograft function and graft and patient survival.</description><identifier>ISSN: 1304-0855</identifier><identifier>EISSN: 2146-8427</identifier><identifier>DOI: 10.6002/ect.2015.0200</identifier><language>eng</language><publisher>Başkent Üniversitesi</publisher><subject>Tıp</subject><ispartof>Experimental and clinical transplantation, 2016-04, Vol.14 (2), p.157-165</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><contributor>Haberal,Mehmet</contributor><creatorcontrib>Shokeir,Ahmed A</creatorcontrib><creatorcontrib>Mashaly,Mohamed Elsayed</creatorcontrib><creatorcontrib>Ismail,Mabrouk I</creatorcontrib><creatorcontrib>Lotfy,Esam E</creatorcontrib><creatorcontrib>Donia,Ahmed F</creatorcontrib><creatorcontrib>Wafa,Ihab W</creatorcontrib><creatorcontrib>Foda,Mohamed A</creatorcontrib><creatorcontrib>Denewar,Ahmed Abdelfattah</creatorcontrib><creatorcontrib>Abbas,Mohamed Hamed</creatorcontrib><title>Frequency of the original kidney disease and its effect on the outcome of kidney transplant in the urology-nephrology center Mansoura University</title><title>Experimental and clinical transplantation</title><description>Objectives: Renal allograft function and graft survival depends on many factors, including the source of the graft, immunologic matching between donor and recipient, incidence of acute rejection, and recurrence of the original kidney disease. This work aimed to evaluate the effects of the original kidney disease on patient and graft survival.
Materials and Methods: This was a retrospective, single-center study that included 2189 kidney transplant recipients who were transplanted at The Urology and Nephrology Centre, Mansoura University, between 1976 and 2010. Of 2189 recipients, 1350 patients with unknown original kidney disease were excluded, with the remaining 839 patients divided into 4 groups according to their original kidney disease.
Results: We found pretransplant dialysis and blood transfusion to be statistically significant among the 4 groups. Regarding induction immunosuppressive therapy, a statistical significance was found between the 4 groups regarding the presence and type of induction therapy, with no statistical significance regarding the type of maintenance immunosuppression. There was no statistical significance between the 4 groups regarding the incidence of acute and chronic rejection. We also found recurrence of original kidney disease to be statistically significant in the 4 groups, particularly in the group that included patients with glomerular disease, where the highest rate of recurrence was reported in patients with focal segmental glomerulosclerosis and membranoproliferative glomerulonephritis, and patient and graft survival was also statistically significant.
Conclusions: The original kidney disease has an effect on renal allograft function and graft and patient survival.</description><subject>Tıp</subject><issn>1304-0855</issn><issn>2146-8427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNotjztPAzEQhC0EElFISe-O6sL6cY-UUUggUhANqSOfvU4Mhx3OPqT7F_xkDl2qmeKb2R1C7hnMCwD-iDrNObB8Dhzgikw4k0VWSV5ekwkTIDOo8vyWzGJ0NUhZllwW1YT8blr87tDrngZL0wlpaN3RedXQT2c89tS4iCoiVd5QlyJFa4dbNPiR7pIOX_gfvvCpVT6eG-UTdSPTtaEJxz7zeD6Nlmr0CVv6OqChaxXde_eDbXSpvyM3VjURZxedkv1m_b56yXZvz9vVcpc5LkXKpMJKa1YrLXLNLDIpqzo3loNQ2kphFryoJIBiohAMjEFdapCsKDmzBa_FlDyMvc6gaoJvnMfDx_DMMD0etk_r5e6Q88VCij9qE2wm</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Shokeir,Ahmed A</creator><creator>Mashaly,Mohamed Elsayed</creator><creator>Ismail,Mabrouk I</creator><creator>Lotfy,Esam E</creator><creator>Donia,Ahmed F</creator><creator>Wafa,Ihab W</creator><creator>Foda,Mohamed A</creator><creator>Denewar,Ahmed Abdelfattah</creator><creator>Abbas,Mohamed Hamed</creator><general>Başkent Üniversitesi</general><scope>IEBAR</scope></search><sort><creationdate>201604</creationdate><title>Frequency of the original kidney disease and its effect on the outcome of kidney transplant in the urology-nephrology center Mansoura University</title><author>Shokeir,Ahmed A ; Mashaly,Mohamed Elsayed ; Ismail,Mabrouk I ; Lotfy,Esam E ; Donia,Ahmed F ; Wafa,Ihab W ; Foda,Mohamed A ; Denewar,Ahmed Abdelfattah ; Abbas,Mohamed Hamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i243t-4ae8cc1bac35c1fe1448b5df203acf43d9268400a136310ddec7c0416721f62b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Tıp</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shokeir,Ahmed A</creatorcontrib><creatorcontrib>Mashaly,Mohamed Elsayed</creatorcontrib><creatorcontrib>Ismail,Mabrouk I</creatorcontrib><creatorcontrib>Lotfy,Esam E</creatorcontrib><creatorcontrib>Donia,Ahmed F</creatorcontrib><creatorcontrib>Wafa,Ihab W</creatorcontrib><creatorcontrib>Foda,Mohamed A</creatorcontrib><creatorcontrib>Denewar,Ahmed Abdelfattah</creatorcontrib><creatorcontrib>Abbas,Mohamed Hamed</creatorcontrib><collection>Idealonline online kütüphane - Journals</collection><jtitle>Experimental and clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shokeir,Ahmed A</au><au>Mashaly,Mohamed Elsayed</au><au>Ismail,Mabrouk I</au><au>Lotfy,Esam E</au><au>Donia,Ahmed F</au><au>Wafa,Ihab W</au><au>Foda,Mohamed A</au><au>Denewar,Ahmed Abdelfattah</au><au>Abbas,Mohamed Hamed</au><au>Haberal,Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency of the original kidney disease and its effect on the outcome of kidney transplant in the urology-nephrology center Mansoura University</atitle><jtitle>Experimental and clinical transplantation</jtitle><date>2016-04</date><risdate>2016</risdate><volume>14</volume><issue>2</issue><spage>157</spage><epage>165</epage><pages>157-165</pages><issn>1304-0855</issn><eissn>2146-8427</eissn><abstract>Objectives: Renal allograft function and graft survival depends on many factors, including the source of the graft, immunologic matching between donor and recipient, incidence of acute rejection, and recurrence of the original kidney disease. This work aimed to evaluate the effects of the original kidney disease on patient and graft survival.
Materials and Methods: This was a retrospective, single-center study that included 2189 kidney transplant recipients who were transplanted at The Urology and Nephrology Centre, Mansoura University, between 1976 and 2010. Of 2189 recipients, 1350 patients with unknown original kidney disease were excluded, with the remaining 839 patients divided into 4 groups according to their original kidney disease.
Results: We found pretransplant dialysis and blood transfusion to be statistically significant among the 4 groups. Regarding induction immunosuppressive therapy, a statistical significance was found between the 4 groups regarding the presence and type of induction therapy, with no statistical significance regarding the type of maintenance immunosuppression. There was no statistical significance between the 4 groups regarding the incidence of acute and chronic rejection. We also found recurrence of original kidney disease to be statistically significant in the 4 groups, particularly in the group that included patients with glomerular disease, where the highest rate of recurrence was reported in patients with focal segmental glomerulosclerosis and membranoproliferative glomerulonephritis, and patient and graft survival was also statistically significant.
Conclusions: The original kidney disease has an effect on renal allograft function and graft and patient survival.</abstract><pub>Başkent Üniversitesi</pub><doi>10.6002/ect.2015.0200</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1304-0855 |
ispartof | Experimental and clinical transplantation, 2016-04, Vol.14 (2), p.157-165 |
issn | 1304-0855 2146-8427 |
language | eng |
recordid | cdi_idealonline_journals_IDEAL_52994 |
source | Freely Accessible Science Journals - check A-Z of ejournals |
subjects | Tıp |
title | Frequency of the original kidney disease and its effect on the outcome of kidney transplant in the urology-nephrology center Mansoura University |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T20%3A32%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-idealonline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Frequency%20of%20the%20original%20kidney%20disease%20and%20its%20effect%20on%20the%20outcome%20of%20kidney%20transplant%20in%20the%20urology-nephrology%20center%20Mansoura%20University&rft.jtitle=Experimental%20and%20clinical%20transplantation&rft.au=Shokeir,Ahmed%20A&rft.date=2016-04&rft.volume=14&rft.issue=2&rft.spage=157&rft.epage=165&rft.pages=157-165&rft.issn=1304-0855&rft.eissn=2146-8427&rft_id=info:doi/10.6002/ect.2015.0200&rft_dat=%3Cidealonline%3EIDEAL_52994%3C/idealonline%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-i243t-4ae8cc1bac35c1fe1448b5df203acf43d9268400a136310ddec7c0416721f62b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |