Role of inflammation and oxidative stress in the etiology of primary ovarian insufficiency

• Published in: Turkish journal of obstetrics and gynecology 2016, Vol.13 (3), p.109-115
• Main Authors: Tunç,Senem Yaman, Ağaçayak,Elif, Görük,Neval Yaman, İçen,Mehmet Sait, Başaranoğlu,Serdar, Yıldızbakan,Ahmet, Gül,Talip, Küsen,Hakan, Kalkanlı Taş,Sevgi, Yüksel,Hatice
• Format: Article
• Language: English
• Subjects: Kadın Hastalıkları; Tıp
• ISSN: 2149-9322; 2149-9330
• DOI: 10.4274/tjod.00334

Objective: The aim of this study was to elucidate the etiology and treatment of primary ovarian insufficiency, which is of unknown cause in 95% of the cases. Materials and Methods: Thirty patients aged 18-40 years who presented to Dicle University Faculty of Medicine Clinic of Obstetrics and Gynecology between June 2012 and January 2014 and were diagnosed as having primary ovarian insufficiency based on their clinical and endocrinologic data, and 30 healthy controls were included in this study. Results: No significant differences were found between patients with primary ovarian insufficiency and control subjects in demographic data and lipid profile levels, thyroid- stimulating hormone, prolactin, and glucose. However, the neutrophil to lymphocyte ratio and levels of follicle-stimulating hormone, luteinizing hormone, total antioxidant status, total oxidant status, and oxidative stress index were significantly higher in patients with primary ovarian insufficiency than in control subjects. In the correlation analysis, follicle-stimulating hormone exhibited a positive correlation with total oxidant status, oxidative stress index, and the neutrophil to lymphocyte ratio (r=0.573** p