Detection of Driver Gene Mutations from Thoracic CT Images Based on LightGBM with Radiomics Features

Lung cancer is one of the most common cancers worldwide and has become a general medical problem. To lessen the risk of death, early detection and treatment is particularly required. The patients can use molecularly targeted drugs when the driver gene mutations of the cancer are detected, but invasi...

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Bibliographic Details
Main Authors: Watanabe, Shion, Kamiya, Tohru, Terasawa, Takashi, Aoki, Takatoshi
Format: Conference Proceeding
Language:English
Subjects:
Computed tomography
Computer Aided Diagnosis
Control systems
Drugs
Feature extraction
History
Lasso
Light Gradient Boosting Machine
Lung cancer
Machine Learning
Radiomics
Solid modeling
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Summary:Lung cancer is one of the most common cancers worldwide and has become a general medical problem. To lessen the risk of death, early detection and treatment is particularly required. The patients can use molecularly targeted drugs when the driver gene mutations of the cancer are detected, but invasive biopsies are required. So, development of new methods to detect it noninvasively and in a short time are expected. we propose a new machine learning method for identifying the presence or absence of driver gene mutations of lung cancer on Thoracic CT Images that is a non-invasive, in a short time, and low-cost CAD (Computer Aided Diagnosis) system. In the proposed method, radiomics features are given as explanatory variables in addition to Thoracic CT Images, and supervised learning using LightGBM is performed to conduct binary classification with/without driver gene mutations.
ISSN:2642-3901
DOI:10.23919/ICCAS55662.2022.10003871