Whispering gallery mode microresonator sensor integrated in exposed core fiber for label-free DNA hybridization detection

A novel optical fiber sensor using exposed-core fiber (ECF) to excite whispering gallery modes (WGMs) within a high refractive index barium titanate glass microsphere is proposed for achieving label-free real-time specific DNA detection. The microsphere is encapsulated into the exposed channel of th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of lightwave technology 2023-07, Vol.41 (13), p.1-7
Main Authors: Zhou, Xue, Wang, Shankun, Li, Xuegang, Zhao, Yong, Zhang, Yanan, Nguyen, Linh Viet, Warren-Smith, Stephen C.
Format: Article
Language:English
Subjects:
Aqueous environments
Aqueous solutions
Barium titanates
Chemical analysis
DNA
DNA Hybridization Detection
Doppler effect
Environmental protection
Exposed-core Fiber
Exposure
Gene sequencing
Glass
Microcavities
Optical fiber sensors
Optical fibers
Optical surface waves
Q factors
Q-factor
Red shift
Refractivity
Sensors
Whispering Gallery Modes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel optical fiber sensor using exposed-core fiber (ECF) to excite whispering gallery modes (WGMs) within a high refractive index barium titanate glass microsphere is proposed for achieving label-free real-time specific DNA detection. The microsphere is encapsulated into the exposed channel of the ECF allowing for physical stability while excited WGMs via the evanescent field. The structure enables the sensing area to be exposed to a large amount of aqueous solution and better contact with the sample to be analyzed. Using a transmission measurement, a high Q-factor in the order of 10 4 is obtained in an aqueous environment. To the best of our knowledge, this is the best Q-factor level obtained by the in fiber WGM sensor in an aqueous environment. Specific sequences of probe DNA are then bound to the surface of the microsphere so that specific detection of complementary DNA can be realized by tracking the wavelength shift the WGM resonance. Experimental results show a red shift of 5.6 pm for complementary DNA hybridization detection and less than 1 pm fluctuation for non-complementary DNA detection. The portable integrated sensor with miniature size has great potential for aqueous environmental sensing applications in the fields of diseases diagnostics, chemical analysis, and environmental protection.
ISSN:0733-8724
1558-2213
DOI:10.1109/JLT.2023.3245655