On Measuring the Dissimilarity between Biological Sequences

The antimicrobial resistance (AMR) of bacteria to antibiotics is tightly connected with their genetic structure changes. Many methods belonging to various disciplines are applied to analyze these genetic changes. The genes involved in AMR undergo different changes. These changes can be analyzed usin...

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Bibliographic Details
Main Authors: Carunta, Alina, Plesu, Mihai
Format: Conference Proceeding
Language:English
Subjects:
Antibiotics
antimicrobial resistance
dissimilarity measures
DNA
Electrical resistance measurement
Immune system
Levenshtein distance
Microorganisms
Needleman-Wunsch algorithm
Scientific computing
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Summary:The antimicrobial resistance (AMR) of bacteria to antibiotics is tightly connected with their genetic structure changes. Many methods belonging to various disciplines are applied to analyze these genetic changes. The genes involved in AMR undergo different changes. These changes can be analyzed using distances between different variants (alleles) of a gene. This paper aims to study the dissimilarity between different variants of the sul2 gene using the Levenshtein distance between the corresponding DNA sequences, a distance based on binary representation and the distance induces by the global alignment scores computed using with the Needleman-Wunsch algorithm.
ISSN:2470-881X
DOI:10.1109/SYNASC57785.2022.00067