Analysis based on the Pharmacodynamics of Blood Cells using Finite Element Analysis Method(FEM)

• Main Authors: M, Sushmitha, V, Abinaya, S, Deepika, R, Kalpana, T, Indumathy
• Format: Conference Proceeding
• Language: English
• Subjects: Analytical models; Chemical reactions; Drugs; Finite Element Analysis; Hemochromatosis; Iron; Iron chelation; Medical treatment; Microfluidics; Multiphysics; Solid modeling; Three-dimensional displays
• ISSN: 2767-7788
• DOI: 10.1109/ICICT57646.2023.10134128

A crucial component of human body is iron, which binds with oxygen to make haemoglobin in red blood cells. The substance turns poisonous when the iron concentration rises. Hemochromatosis is one such condition and is characterized by an excessive accumulation of iron (Fe3+) in the blood. This additional iron builds up in the liver, pancreas, heart, joints, and skin, where it can cause dark skin pigmentation, liver cirrhosis, and arrhythmias, among other problems. If left untreated, it can even be fatal. Hemochromatosis is classified into two types: primary hemochromatosis, which is inherited and caused by a mutation in the HFE gene, and secondary hemochromatosis, which is caused by a diet that causes the blood to become unusually iron-enriched. Typical symptoms include shortness of breath, fatigue, fever, nausea, and nausea. Treatment options include chelation therapy and phlebotomy. Chelation is used by patients who have ailments such as anaemia, cardiac problems, and so on. Deferasirox, Deferiprone, and Deferoxamine are used as part of the chelation therapy to lower the blood's iron concentration. By including chelating medication and blood cells into a model, the effectiveness of the medication using COMSOL is investigated. Ironconcentration of the drug decreases following the chemical reaction. During the analysis of the 3D model with the Multiphysics coupling, variables including velocity and pressure profiles were examined.