Contact Activation in Dielectric Blood Coagulometry: A Comparison of Screen-Printed and Sputtered Gold Electrodes of ClotChip Microfluidic Sensor

This letter investigates the effect of surface roughness on the kinetics of whole blood coagulation through a comparative study of two different electrode fabrication techniques, i.e., screen printing and sputtering, for a microfluidic dielectric sensor termed ClotChip. Featuring a 3D parallel-plate...

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Bibliographic Details
Published in:IEEE sensors letters 2024-07, Vol.8 (7), p.1-4
Main Authors: Alizadeh, Hanif, Abonga, Calvin, Delianides, Christopher A., Pourang, Sina, Suster, Michael A., Mohseni, Pedram
Format: Article
Language:English
Subjects:
Blood
Blood coagulation
Coagulation
Comparative studies
contact activation
dielectric blood coagulometry
dielectric spectroscopy (DS)
Dielectrics
Electrodes
Gold
hemostasis
Kinetics
microfluidic sensor
Microfluidics
Parameters
Permittivity
point-of-care diagnostics
Polymethyl methacrylate
Rough surfaces
Screen printing
Senor phenomena
sensor characterization
Substrates
Surface roughness
Surface roughness effects
Trypsin inhibitors
whole blood coagulation
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Summary:This letter investigates the effect of surface roughness on the kinetics of whole blood coagulation through a comparative study of two different electrode fabrication techniques, i.e., screen printing and sputtering, for a microfluidic dielectric sensor termed ClotChip. Featuring a 3D parallel-plate capacitive sensing structure with gold sensing and floating electrodes deposited on polymethyl methacrylate plastic substrates, we have previously shown that ClotChip can measure the temporal variation in the normalized real permittivity of a coagulating whole blood sample (
ISSN:2475-1472
2475-1472
DOI:10.1109/LSENS.2024.3408689