Spatiotemporal Imaging of Extra-/Intracellular Ion Concentrations by Multifrequency Complex Electrical Impedance Tomography (mfc-EIT)

The multifrequency complex electrical impedance tomography (mfc-EIT) has been proposed to image the spatiotemporal extra-/intracellular ion concentrations. In mfc-EIT, four frequency-dependent Jacobian matrices described by the partial derivatives of complex impedance (resistance and reactance) with...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on instrumentation and measurement 2025, Vol.74, p.1-12
Main Authors: Kawashima, Daisuke, Li, Songshi, Obara, Hiromichi, Takei, Masahiro
Format: Article
Language:English
Subjects:
Complex Jacobian matrix
Conductivity
Electric fields
Electrical impedance
Electrical impedance tomography
electrical impedance tomography (EIT)
Electrodes
Extracellular
extracellular ion concentration
Frequency response
Image reconstruction
Impedance
intracellular ion concentration
Ion channels
Ion concentration
ion transfer
Ions
Jacobi matrix method
Jacobian matrices
Jacobian matrix
Permittivity
Reactance
System-on-chip
Tomography
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The multifrequency complex electrical impedance tomography (mfc-EIT) has been proposed to image the spatiotemporal extra-/intracellular ion concentrations. In mfc-EIT, four frequency-dependent Jacobian matrices described by the partial derivatives of complex impedance (resistance and reactance) with respect to complex conductivity (conductivity \sigma and relative permittivity \varepsilon ) as a function of radial frequency \omega are newly introduced as a complex Jacobian matrix. The mfc-EIT inversely reconstructs the \sigma and \varepsilon images as a function of frequency from the complex impedance. Based on the electric field simulation, the \sigma and \varepsilon images reconstructed by mfc-EIT and conventional EIT with a general Jacobian matrix are evaluated by spectral stabilities which is an indicator of reasonable spectral trend. The \sigma and \varepsilon images by mfc-EIT have lower ( \sigma : 2.7\times 10^{-9} and \varepsilon : 3.0\times 10^{-4} ) than those by conventional EIT ( \sigma : 5.5\times 10^{-8} and \varepsilon : 5.6\times 10^{-3} ), which indicates that mfc-EIT reconstructs the reasonable frequency response. The mfc-EIT is also applied to the imaging of the extra/intrace-cellular ion transfer around cell-spheroids in experim
ISSN:0018-9456
1557-9662
DOI:10.1109/TIM.2024.3502740