Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands

The adhesive contacts between neutrophil and endothelium are mediated by /spl beta/-integrin-endothelial ligand interactions. Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vit...

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Bibliographic Details
Main Authors: Lomakina, E.B., Waugh, R.E.
Format: Conference Proceeding
Language:English
Subjects:
Adhesives
Biomedical engineering
Blood
Extracellular
Fluorescence
In vitro
In vivo
Surface morphology
Surface treatment
Temperature
Online Access:Request full text
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Summary:The adhesive contacts between neutrophil and endothelium are mediated by /spl beta/-integrin-endothelial ligand interactions. Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vitro by Mg/sup 2+/, enabling adhesion without causing the whole cell activation. Formation of adhesive contacts is modulated both by temperature and the duration of contact between the neutrophil and the integrin ligand-coated surface.
ISSN:1094-687X
1558-4615
DOI:10.1109/IEMBS.2002.1136840