Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands

The adhesive contacts between neutrophil and endothelium are mediated by /spl beta/-integrin-endothelial ligand interactions. Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vit...

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Main Authors: Lomakina, E.B., Waugh, R.E.
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Waugh, R.E.
description The adhesive contacts between neutrophil and endothelium are mediated by /spl beta/-integrin-endothelial ligand interactions. Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vitro by Mg/sup 2+/, enabling adhesion without causing the whole cell activation. Formation of adhesive contacts is modulated both by temperature and the duration of contact between the neutrophil and the integrin ligand-coated surface.
doi_str_mv 10.1109/IEMBS.2002.1136840
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identifier ISSN: 1094-687X
ispartof Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, 2002, Vol.1, p.354-355 vol.1
issn 1094-687X
1558-4615
language eng
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source IEEE Electronic Library (IEL) Conference Proceedings
subjects Adhesives
Biomedical engineering
Blood
Extracellular
Fluorescence
In vitro
In vivo
Surface morphology
Surface treatment
Temperature
title Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands
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