Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands
The adhesive contacts between neutrophil and endothelium are mediated by /spl beta/-integrin-endothelial ligand interactions. Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vit...
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creator | Lomakina, E.B. Waugh, R.E. |
description | The adhesive contacts between neutrophil and endothelium are mediated by /spl beta/-integrin-endothelial ligand interactions. Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vitro by Mg/sup 2+/, enabling adhesion without causing the whole cell activation. Formation of adhesive contacts is modulated both by temperature and the duration of contact between the neutrophil and the integrin ligand-coated surface. |
doi_str_mv | 10.1109/IEMBS.2002.1136840 |
format | conference_proceeding |
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Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vitro by Mg/sup 2+/, enabling adhesion without causing the whole cell activation. 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Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vitro by Mg/sup 2+/, enabling adhesion without causing the whole cell activation. Formation of adhesive contacts is modulated both by temperature and the duration of contact between the neutrophil and the integrin ligand-coated surface.</description><subject>Adhesives</subject><subject>Biomedical engineering</subject><subject>Blood</subject><subject>Extracellular</subject><subject>Fluorescence</subject><subject>In vitro</subject><subject>In vivo</subject><subject>Surface morphology</subject><subject>Surface treatment</subject><subject>Temperature</subject><issn>1094-687X</issn><issn>1558-4615</issn><isbn>0780376129</isbn><isbn>9780780376120</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2002</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><recordid>eNp9j71uAjEQhK2QSCGBF0iafYEj6zvfXwsCQUFFihSR0AYvnCNjo7MB5e3jgpppRjPfNCPEm8SJlNh-rObr6WaSI-YpF1Wj8EEMZVk2mapkORAvWDdY1JXM28cEsFVZ1dRfz2Icwi8mqVIq1Q7F98L3R4rGO_B7IN1xMBeGnXeRdjHAD8crswPH59j7U2dsAHI69aRDmlFkDVcTO2CnfezYGrJgzSGNwkg87ckGHt_8Vbwv5p-zZWaYeXvqzZH6v-3tQHGf_gN6fUfv</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Lomakina, E.B.</creator><creator>Waugh, R.E.</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope></search><sort><creationdate>2002</creationdate><title>Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands</title><author>Lomakina, E.B. ; Waugh, R.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ieee_primary_11368403</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adhesives</topic><topic>Biomedical engineering</topic><topic>Blood</topic><topic>Extracellular</topic><topic>Fluorescence</topic><topic>In vitro</topic><topic>In vivo</topic><topic>Surface morphology</topic><topic>Surface treatment</topic><topic>Temperature</topic><toplevel>online_resources</toplevel><creatorcontrib>Lomakina, E.B.</creatorcontrib><creatorcontrib>Waugh, R.E.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Xplore</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lomakina, E.B.</au><au>Waugh, R.E.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands</atitle><btitle>Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology</btitle><stitle>IEMBS</stitle><date>2002</date><risdate>2002</risdate><volume>1</volume><spage>354</spage><epage>355 vol.1</epage><pages>354-355 vol.1</pages><issn>1094-687X</issn><eissn>1558-4615</eissn><isbn>0780376129</isbn><isbn>9780780376120</isbn><abstract>The adhesive contacts between neutrophil and endothelium are mediated by /spl beta/-integrin-endothelial ligand interactions. Binding of integrins to their ligands ICAM-1 and VCAM-1 occurs only when integrins are in an "activated" conformation. The high affinity state can be induced in vitro by Mg/sup 2+/, enabling adhesion without causing the whole cell activation. Formation of adhesive contacts is modulated both by temperature and the duration of contact between the neutrophil and the integrin ligand-coated surface.</abstract><pub>IEEE</pub><doi>10.1109/IEMBS.2002.1136840</doi></addata></record> |
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ispartof | Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, 2002, Vol.1, p.354-355 vol.1 |
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source | IEEE Electronic Library (IEL) Conference Proceedings |
subjects | Adhesives Biomedical engineering Blood Extracellular Fluorescence In vitro In vivo Surface morphology Surface treatment Temperature |
title | Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands |
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