Pathway logic modeling of protein functional domains in signal transduction

We describe the application of an approach called pathway logic to the symbolic modeling of protein functional domains (PFDs). We show how signal transduction processes can be modeled at different levels of abstraction involving either an overall state of a protein or its PFDs and their interactions...

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Bibliographic Details
Main Authors: Talcott, C., Eker, S., Knapp, M., Lincoln, P., Laderoute, K.
Format: Conference Proceeding
Language:English
Subjects:
Amino acids
Biological system modeling
Biomembranes
Cells (biology)
Logic
Phase frequency detector
Proteins
Recruitment
Signal analysis
Signal processing
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Description
Summary:We describe the application of an approach called pathway logic to the symbolic modeling of protein functional domains (PFDs). We show how signal transduction processes can be modeled at different levels of abstraction involving either an overall state of a protein or its PFDs and their interactions, and how the resulting signalling network can be queried using formal methods tools.
DOI:10.1109/CSB.2003.1227425