The particle tracking silicon microscope PTSM

• Main Authors: Sadrozinski, H.F.-W., Bashkirov, V., Bruzzi, M., Ebrahimi, M., Feldt, J., Keeney, B., Martinez-McKinney, F., Menichelli, D., Nelson, G., Schulte, R.W.M., Seiden, A., Spencer, E., Wray, J., Lan Zhang
• Format: Conference Proceeding
• Language: English
• Subjects: Biological systems; Cells (biology); Energy loss; Genetic mutations; Microscopy; Particle tracking; Radiation detectors; Radio control; Silicon radiation detectors; Strips
• ISSN: 1082-3654; 2577-0829
• DOI: 10.1109/NSSMIC.2003.1351851

A novel position- and energy-sensitive particle detector for radiobiological application is described. The aim is to support research in radiation response of biological systems, for example in the induction of mutations in C elegans, where precise knowledge of location and intensity of the radiation is crucial to understand radiation sensitivity of individual cells. The "Particle Silicon Tracking Microscope" (PTSM) consists of a silicon strip detector in direct contact with radiobiological samples (e.g., C elegans), such that the location and intensity of particle radiation can be controlled at the 10 /spl mu/m scale. The readout is performed with low-noise readout electronics, which allows the determination of the particle's position from the hit strip address and its energy from the specific energy loss. In our implementation, the energy loss is measured through the time-over-threshold (TOT). The noise rate at acceptable thresholds is so low that the single particles can be detected with 100% efficiency. The performance of the front-end ASIC is described, and the results of initial environmental tests are reported. These include placing biological samples and saline solutions in direct contact with the silicon detectors.