Saccadic parameters for early identification of neuronopathic Gaucher's disease

For a successful treatment of the neurological form of Gaucher's disease ,an early identification is necessary. Often an alteration of the horizontal saccadic eye movements constitutes the first sign of a central nervous system involvement. In order to obtain an early identification of the neur...

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Main Authors: Accardo, A.P., Pensiero, S., Perissutti, P.
Format: Conference Proceeding
Language:English
Subjects:
Biochemistry
Biological cells
Bones
Central nervous system
Delay
Diseases
Expert systems
Eye movement
Gaucher's disease
Hemorrhaging
Medical treatment
Pediatrics
skewness
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creator Accardo, A.P.
Pensiero, S.
Perissutti, P.
description For a successful treatment of the neurological form of Gaucher's disease ,an early identification is necessary. Often an alteration of the horizontal saccadic eye movements constitutes the first sign of a central nervous system involvement. In order to obtain an early identification of the neuronopathic forms of the disease, often masked by the use of the enzyme replacement therapy, the classical saccadic characteristics (latency, amplitude vs. duration and amplitude vs. peak velocity relationships) are not usable. This work studies if some other parameters (mean velocity/peak velocity, kurtosis, skewness, asymmetry), are able to describe the saccadic velocity profiles, could be considered to build an expert system able to reach the aim.
doi_str_mv 10.1109/IEMBS.2004.1403254
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source IEEE Electronic Library (IEL) Conference Proceedings
subjects Biochemistry
Biological cells
Bones
Central nervous system
Delay
Diseases
Expert systems
Eye movement
Gaucher's disease
Hemorrhaging
Medical treatment
Pediatrics
skewness
title Saccadic parameters for early identification of neuronopathic Gaucher's disease
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