Effect of Cellular Elements on Pressure-Velocity Relationship in Mice

The effect of cellular elements in the blood on peripheral vascular function in mice was evaluated using the pressure-velocity relationships in the iliac arteries of 5 wild type (WT) and 3 polycythemic (MH) mice. Pressure was obtained using a fluid filled catheter in the left iliac artery and blood...

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Bibliographic Details
Main Authors: Reddy, A.K., Taffet, G.E., Prchal, J.F., Michael, L.H., Entman, M.L., Hartley, C.J.
Format: Conference Proceeding
Language:English
Subjects:
Abdomen
Arteries
Blood
Catheters
Doppler ultrasound
Fluid flow measurement
Humans
Mice
mouse iliac artery
peripheral vascular resistance
polycythemia
Pressure measurement
pulsatility index
Pulse measurements
resistance index
Velocity measurement
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Summary:The effect of cellular elements in the blood on peripheral vascular function in mice was evaluated using the pressure-velocity relationships in the iliac arteries of 5 wild type (WT) and 3 polycythemic (MH) mice. Pressure was obtained using a fluid filled catheter in the left iliac artery and blood velocity was measured in the right iliac artery using a 20 MHz pulsed Doppler probe. The proximal aorta was then occluded for one minute to allow flow velocity to decay to zero. The pressure-velocity relationship in the diastolic phase was determined before and after aortic occlusion. In both groups the pressure-velocity relationship was almost linear and the slopes were similar. However, the extrapolated zero-velocity intercept was significantly higher for the MH than WT mice before (55.4 ± 4.0 vs. 36.2 ± 4.1 mmHg, p
DOI:10.1109/IEMBS.2004.1404044