A model of the respiratory central pattern generator

We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model was designed as a network of Hodgkin-Huxley type medullary neurons under the hypothesis that synaptic and network effects pred...

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Bibliographic Details
Main Authors: Amini, B., Bidani, A., Zwischenberger, J.B., Clark, J.W.Jr
Format: Conference Proceeding
Language:English
Subjects:
Anatomy
Biological system modeling
Biology computing
Biomedical engineering
Computational biology
Consortia
Frequency
Lungs
Nerve fibers
Neurons
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Summary:We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model was designed as a network of Hodgkin-Huxley type medullary neurons under the hypothesis that synaptic and network effects predominate over ionic influences in determining the pattern of firing seen in individual neurons. After obtaining satisfactory mimicry of these patterns we validated the model to a different set of data in order to examine its robustness in the face of transient perturbations.
DOI:10.1109/IEMBS.2004.1404270