The effect of electrical charge on drug delivery through skin

Drug delivery through skin has benefits such as its conveniences of providing controlled dosage to patients. In this article we investigate the effects of electrical characteristics of molecules on their effectiveness in transdermal drug delivery. Using multiphoton microscopy, we imaged the skin tre...

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Bibliographic Details
Main Authors: Jie Chen, Tsung-Kai Chiu, Wen Lo, Sung-Jan Lin, Shiou-Hwa Jee, Chen-Yuan Dong
Format: Conference Proceeding
Language:English
Subjects:
Biomedical imaging
Drug delivery
Educational institutions
Electric variables
Fluorescence
Hospitals
Microscopy
Pharmaceuticals
Physics
Skin
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Summary:Drug delivery through skin has benefits such as its conveniences of providing controlled dosage to patients. In this article we investigate the effects of electrical characteristics of molecules on their effectiveness in transdermal drug delivery. Using multiphoton microscopy, we imaged the skin treated with fluorescent model drugs having different charges. We will present both the images obtained at different depths and axial fluorescence intensity profiles. Multiphoton microscopy is a useful technique for mechanistic analysis in transdermal drug delivery.
DOI:10.1109/APBP.2004.1412338