A model of chromosome longitudinal structure

Symbolic nucleotide sequences are converted into digital genomic signals by using a complex representation derived from a tetrahedral vector representation of nucleotides. It is shown that, for large scales, the unwrapped phase of such signals is invariant with respect to the inversion of DNA double...

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Bibliographic Details
Main Author: Cristea, P.D.
Format: Conference Proceeding
Language:English
Subjects:
Bioinformatics
Biological cells
DNA
Genomics
Large-scale systems
Microorganisms
Proteins
Sequences
Signal processing
Viruses (medical)
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Summary:Symbolic nucleotide sequences are converted into digital genomic signals by using a complex representation derived from a tetrahedral vector representation of nucleotides. It is shown that, for large scales, the unwrapped phase of such signals is invariant with respect to the inversion of DNA double helix segments, while the cumulated phase is quite conservative for uniformly distributed single nucleotide polymorphisms (SNP). By re-orienting chromosome coding regions, a "hidden" linear variation of the cumulated phase has been revealed, along with the conspicuous almost linear variation of the unwrapped phase. A model of the chromosome longitudinal structure has been inferred on these bases.
DOI:10.1109/NEUREL.2004.1416560