Young's modulus reconstruction for assessing vulnerable atherosclerotic plaque composition in vivo

Intravascular ultrasound (IVUS) elastography visualizes local arterial radial strain in a so-called elastogram to detect vulnerable, rupture-prone plaques. However, due to the unknown arterial stress distribution, this elastogram cannot be directly interpreted as a plaque composition image. To overc...

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Bibliographic Details
Main Authors: Baldewsing, R.A., Schaar, J.A., Mastik, F., Oomens, C.W.J., van der Steen, A.F.W.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical engineering
Biomedical measurements
Capacitive sensors
Finite element methods
Geometry
Image reconstruction
In vitro
In vivo
Strain measurement
Visualization
Online Access:Request full text
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Summary:Intravascular ultrasound (IVUS) elastography visualizes local arterial radial strain in a so-called elastogram to detect vulnerable, rupture-prone plaques. However, due to the unknown arterial stress distribution, this elastogram cannot be directly interpreted as a plaque composition image. To overcome this limitation, we have developed a method that reconstructs a Young's modulus image from an elastogram. This method could successfully reconstruct a plaque from an elastogram that was measured from vessel-mimicking material and measured in vitro from a human coronary plaque. Finally, it was applied on an elastogram measured in vivo from a coronary plaque of a patient.
ISSN:1051-0117
DOI:10.1109/ULTSYM.2004.1417740