Use of a Genetic Algorithm for Neuron Model Specification

We have used a genetic algorithm (GA) to develop simple firing neuron models consisting of a single compartment with one inward and one outward current. The GA not only chooses the model parameters, but also chooses the formulation of the ionic currents (i.e. single-variable, two-variable, instantan...

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Bibliographic Details
Main Authors: Gerken, W.C., Purvis, L.K., Butera, R.J.
Format: Conference Proceeding
Language:English
Subjects:
Biological cells
Biological information theory
Biological system modeling
Biomedical computing
Biomedical engineering
Biomedical measurements
Biomembranes
Decoding
Genetic algorithms
Neurons
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Summary:We have used a genetic algorithm (GA) to develop simple firing neuron models consisting of a single compartment with one inward and one outward current. The GA not only chooses the model parameters, but also chooses the formulation of the ionic currents (i.e. single-variable, two-variable, instantaneous, or leak). The fitness function of the GA compares the output of the GA generated models to an I-F curve of a nominal Morris-Lecar (ML) model. Initially, several different classes of models compete among the population. However, the GA converges to a population containing only ML-type firing models with an instantaneous inward and single-variable outward current. Simulations where ML-type models are not allowed in the population are also investigated. This GA approach allows the exploration of a universe of feasible model classes that is less constrained by model formulation assumptions than traditional parameter estimation approaches
ISSN:1948-3546
1948-3554
DOI:10.1109/CNE.2005.1419618