Unit cell analysis and characterization of three-dimensional two-phase tissue scaffolds

Three-dimensional (3D) porous tissue scaffolds are being engineered to promote cell attachment, cell proliferation and functioning heterogeneous tissue formation. A scaffold's structure and transport capabilities need to mimic cells' natural geometrical and architectural environment and wi...

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Bibliographic Details
Main Authors: Gomez, C., Demirci, M.F., Sun, W., Shokoufandeh, A.
Format: Conference Proceeding
Language:English
Subjects:
Assembly
Biodegradable materials
Biological materials
Biological tissues
Cells (biology)
Computer architecture
Fabrication
Informatics
Mechanical factors
Tissue engineering
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Description
Summary:Three-dimensional (3D) porous tissue scaffolds are being engineered to promote cell attachment, cell proliferation and functioning heterogeneous tissue formation. A scaffold's structure and transport capabilities need to mimic cells' natural geometrical and architectural environment and will need to consistently provide a flux throughout the scaffold to deliver materials for growth and waste removal. This paper presents our work on establishing a connectivity characterization of designed unit cell tissue structures for surface alignment between units to insure both geometric connectivity and mass and fluid transport within a heterogeneous tissue scaffold to meet both structural and biological requirements for cell growth and tissue growth. To capture this information, skeletal representations of the unit cell structures have been utilized for subsequent assembly processes.
ISSN:2160-6986
2160-7028
DOI:10.1109/NEBC.2005.1431975