Microarray Analysis of Ovarian Cancer

Microarray experiments were performed to normal ovaries, benign ovarian tumor and stage I and III of ovarian cancer. By treating benign ovarian tumor as pre-cancerous stage and comparing to later stages of ovarian cancer we identified 46 genes overly expressed in early-staged cancer. We also identif...

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Bibliographic Details
Main Authors: Huang, G.S., Yao-Ching Hung, Ann Chen, Meng-Yen Hong
Format: Conference Proceeding
Language:English
Subjects:
Benign tumors
Bioinformatics
Cancer detection
early diagnostic marker
Gene expression
Genomics
Hospitals
Medical diagnostic imaging
Microarray
Nanotechnology
Neoplasms
ovarian cancer
Pathology
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Summary:Microarray experiments were performed to normal ovaries, benign ovarian tumor and stage I and III of ovarian cancer. By treating benign ovarian tumor as pre-cancerous stage and comparing to later stages of ovarian cancer we identified 46 genes overly expressed in early-staged cancer. We also identified over-expressed genes at all stages of ovarian tumor/cancer. The over-expressed genes might be alternative candidates for developing early diagnostic markers. JUN and nuclear receptor subfamily genes were repeatedly identified in the group of down-regulated genes indicating their important regulatory roles in the oncogenesis of ovary
ISSN:1062-922X
2577-1655
DOI:10.1109/ICSMC.2005.1571282