Prediction of coronary artery disease progression in human from numerically determined endothelial shear stress

Using a technique in which intravascular ultrasound images are fused with two planes of angiography, blood flow is measured, and the Navier Stokes equations are solved in 3 dimensions, we have studied the remodeling characteristic of 55 human coronary arteries and the relationship of endothelial she...

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Bibliographic Details
Main Authors: Feldman, C.L., Coskun, A.U., Stone, P.H.
Format: Conference Proceeding
Language:English
Subjects:
Angiography
Arteries
Blood flow
Coronary arteriosclerosis
Electronic switching systems
Fluid flow measurement
Humans
Stress measurement
Ultrasonic imaging
Ultrasonic variables measurement
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Summary:Using a technique in which intravascular ultrasound images are fused with two planes of angiography, blood flow is measured, and the Navier Stokes equations are solved in 3 dimensions, we have studied the remodeling characteristic of 55 human coronary arteries and the relationship of endothelial shear stress (ESS) to remodeling and plaque progression in 13 human arteries. Results indicate that the remodeling characteristics of 87% of coronaries with minimal luminal narrowing are constant along the length of the artery: 60% percent demonstrate compensatory remodeling; 19% exhibit under-remodeling (consistent with stable CAD) and 21% exhibit excessive remodeling (consistent with unstable syndromes). Serial studies show that plaque progresses almost exclusively in regions of low ESS (
ISSN:0276-6574
2325-8853
DOI:10.1109/CIC.2005.1588045