Computational fluid dynamics model for optimal flow injection analysis biosensor design

This paper presents the optimization of a flow injection analysis (FIA) biosensor with respect to its design and operational parameters such as flow cell geometry, microfluidic channel dimensions, and flow rate. Since it is time consuming and costly to investigate the effect of each factor on the bi...

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Bibliographic Details
Main Authors: Vermeir, S., Verboven, P., Atalay, Y.T., Nicolai, B.M., Lammertyn, J., Irudayaraj, J.
Format: Conference Proceeding
Language:English
Subjects:
Biosensors
Computational fluid dynamics
Computational modeling
Delay
Design optimization
Detectors
Geometry
Microfluidics
Navier-Stokes equations
Sugar
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Summary:This paper presents the optimization of a flow injection analysis (FIA) biosensor with respect to its design and operational parameters such as flow cell geometry, microfluidic channel dimensions, and flow rate. Since it is time consuming and costly to investigate the effect of each factor on the biosensor performance by building it, computational fluid dynamics (CFD) theory is presented as a great tool for finding optimal parameter values. This modeling approach has a high potential in the design of high accuracy FIA-biosensors, regardless of the chosen enzyme substrate system. As an example the optimal design for a glucose/glucose oxidase FIA biosensor is calculated with the CFD theory
ISSN:1930-0395
2168-9229
DOI:10.1109/ICSENS.2005.1597712