PET reconstruction with system matrix derived from point source measurements

The quality of images reconstructed by statistical iterative methods depends on an accurate model of the relationship between image space and projection space through the system matrix. The elements of a system matrix on the HiRez scanner from CPS Innovations were acquired by positioning a point sou...

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Bibliographic Details
Published in:IEEE transactions on nuclear science 2006-02, Vol.53 (1), p.152-159
Main Authors: Panin, V.Y., Kehren, F., Rothfuss, H., Hu, D., Michel, C., Casey, M.E.
Format: Article
Language:English
Subjects:
Image reconstruction
Iterative methods
Iterative reconstruction
Noise
Parameter estimation
PET
Physics
Point sources
Position (location)
Position measurement
Positron emission tomography
Projection
PSF modeling
Reconstruction
Scanners
Software standards
Solid modeling
Studies
Technological innovation
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Summary:The quality of images reconstructed by statistical iterative methods depends on an accurate model of the relationship between image space and projection space through the system matrix. The elements of a system matrix on the HiRez scanner from CPS Innovations were acquired by positioning a point source at different positions in the scanner field of view. Then, a whole system matrix was derived by processing the responses in projection space. Such responses included both geometrical and detection physics components of the system matrix. The response was parameterized to correct for point source location, smooth projection noise and the whole system matrix was derived. The model accounts for axial compression (span) used on the scanner. The projection operator for iterative reconstruction was constructed using the estimated response parameters. Computer-generated and acquired data were used to compare reconstruction obtained by the HiRez standard software and that produced by better modeling. Results showed that better resolution and noise property can be achieved with the modeled system matrix.
ISSN:0018-9499
1558-1578
DOI:10.1109/TNS.2005.862979