Biologic computational building blocks

Methods to represent the biological activity of oxidoreductase enzymes using logic state diagrams and to simulate the enzymes' functionings using synchronous sequential digital circuits are presented. The steps of this transform from biologics to logic involve the enzymes 'electron kinetic...

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Bibliographic Details
Published in:Computer (Long Beach, Calif.) Calif.), 1992-11, Vol.25 (11), p.22-29
Main Authors: Capstick, M.H., Marnane, W.P.L., Pethig, R.
Format: Article
Language:English
Subjects:
Biochemistry
Biological system modeling
Biology computing
Circuit simulation
Computational modeling
Digital circuits
Electrons
Kinetic theory
Logic
Sequential circuits
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Summary:Methods to represent the biological activity of oxidoreductase enzymes using logic state diagrams and to simulate the enzymes' functionings using synchronous sequential digital circuits are presented. The steps of this transform from biologics to logic involve the enzymes 'electron kinetic behavior, which reveals the basic reaction pathways of the enzyme building blocks. Because these pathways are well defined, with each enzyme going through several different conformations, each conformation can be defined in terms of a logic state. The definitions can be used to describe a state machine for the enzyme building block.< >
ISSN:0018-9162
1558-0814
DOI:10.1109/2.166401