UV Excimer Lamp Irradiation of Fibroblasts: The Influence on Antioxidant Homeostasis

UV excimer lamps are efficient and economical narrowband sources of UVB and UVC radiation. Potentially, these lamps may be used in bacterial disinfection or in minor cosmetic procedures, but safety tests are necessary. For this purpose, cellular damage induced by the UV radiation is assessed. 3T3 mo...

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Bibliographic Details
Published in:IEEE transactions on plasma science 2006-08, Vol.34 (4), p.1359-1364
Main Authors: Erofeev, M.V., Kieft, I.E., Sosnin, E.A., Stoffels, E.
Format: Article
Language:English
Subjects:
Absorption
Bacteria
Cells
Cellular
Damage
Disinfection & disinfectants
DNA
excilamp
Excimers
fibroblast
Fibroblasts
Glutathione
Immune system
Injuries
Irradiation
Lamps
Microorganisms
oxidative stress
Proteins
Skin
Stress
Ultraviolet radiation
UV exciplex lamp
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Summary:UV excimer lamps are efficient and economical narrowband sources of UVB and UVC radiation. Potentially, these lamps may be used in bacterial disinfection or in minor cosmetic procedures, but safety tests are necessary. For this purpose, cellular damage induced by the UV radiation is assessed. 3T3 mouse fibroblasts are used as a model system. It is found that lethal damage occurs above a certain wavelength-dependent threshold dose. Furthermore, the antioxidant balance of the cells is influenced; glutathione levels are usually depleted, both under and above the lethal threshold. A striking increase of glutathione level is observed after UVC irradiation. This is attributed to an enhanced repair activity as a response to acute oxidative stress induced by UVC. In contrast to UVC, low-power irradiation with UVB seems to induce very little cellular damage
ISSN:0093-3813
1939-9375
DOI:10.1109/TPS.2005.876503