Magnetic Properties, Self-Temperature Rising Characteristics, and Biocompatibility of NiFe 2O 4Nanoparticles for Hyperthermia Applications

This paper reports first on the very promising self-heating and temperature rising characteristics of solid-state NiFe 2 O 4 nanoparticles for hyperthermia applications. NiFe 2 O 4 nanoparticles were prepared by using both the "high temperature thermal decomposition method (HTTD)" and the...

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Bibliographic Details
Published in:IEEE transactions on magnetics 2006-10, Vol.42 (10), p.2833-2835
Main Authors: Sang Won Lee, Seongtae Bae, Takemura, Y., Yamashita, E., Kunisaki, J., Zurn, S., Chul Sung Kim
Format: Article
Language:English
Subjects:
Biocompatibility
Hyperthermia
In vivo
Magnetic circuits
Magnetic moments
Magnetic properties
Nanoparticles
NiFe
self-heating
Solid state circuits
SQUIDs
Temperature
Thermal decomposition
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Summary:This paper reports first on the very promising self-heating and temperature rising characteristics of solid-state NiFe 2 O 4 nanoparticles for hyperthermia applications. NiFe 2 O 4 nanoparticles were prepared by using both the "high temperature thermal decomposition method (HTTD)" and the "newly modified sol-gel" methods. The magnetic properties and cell-cytotoxic properties of the synthesized NiFe 2 O 4 nanoparticles were investigated to consider these nanoparticles for in vivo hyperthermia applications. The saturation magnetic moments measured by a high sensitive SQUID were between 43.0 and 47.6 emu/g. The cell survival rates of NiFe 2 O 4 and chitosan coated NiFe 2 O 4 , which were determined by MTT assay, around 85 % and 98.8 %, respectively. The maximum self-heating temperature induced by our specially designed RF-MRI modified L-C circuit was 47.3degC and the frequency and magnetic field product, H 0 f was 1.07 times 10 9 Am -1 s -1
ISSN:0018-9464
1941-0069
DOI:10.1109/TMAG.2006.879142