A microcontinuum model of electrokinetic coupling in the extracellular matrix: perturbation formulation and solution

A microcontinuum model is formulated to describe electrokinetic transduction interactions and transport in the extracellular matrix (ECM). A unit cell approach is used in which the ECM is modeled as an ordered array of charged solid cylinders surrounded by a diffuse double layer. The model includes...

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Bibliographic Details
Main Authors: Chammas, P., Eisenberg, S.R.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical engineering
Capacitive sensors
Electric potential
Electrochemical machining
Electrokinetics
Engine cylinders
Extracellular
Fluid flow
Phased arrays
Solid modeling
Online Access:Request full text
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Summary:A microcontinuum model is formulated to describe electrokinetic transduction interactions and transport in the extracellular matrix (ECM). A unit cell approach is used in which the ECM is modeled as an ordered array of charged solid cylinders surrounded by a diffuse double layer. The model includes the effects of overlapping diffuse double layers and the associated electrokinetic coupling within the bulk of the unit cell as exist under physiological conditions. A system of coupled differential equations is developed to describe the electrokinetic coupling within the unit cell. A perturbation expansion of the governing system is solved using the numerical grid generation technique and the electromechanical coupling coefficients for articular cartilage are determined.< >
DOI:10.1109/IEMBS.1994.415273