An Inductance-based Sensor for DNA Hybridization Detection

This paper introduces an inductance-based sensor for detection of DNA hybridization and investigates its performance by means of computer simulation. In order to detect the occurrence of hybridization, single strand target DNA's are tagged with magnetic beads. Target DNA's are then exposed...

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Bibliographic Details
Main Authors: Azimi, S.M., Bahmanyar, M.R., Zolgharni, M., Balachandran, W.
Format: Conference Proceeding
Language:English
Subjects:
Biosensors
Coils
DNA
DNA Sensor
Inductance
Magnetic Bead
Magnetic flux
Magnetic Sensor
Magnetic sensors
Magnetic separation
Permeability
Probes
Spirals
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Description
Summary:This paper introduces an inductance-based sensor for detection of DNA hybridization and investigates its performance by means of computer simulation. In order to detect the occurrence of hybridization, single strand target DNA's are tagged with magnetic beads. Target DNA's are then exposed to known single strand probe DNA's which are immobilized on a surface in the proximity of a spiral coil with a specific design. After hybridization, the expected variations in the coil inductance due to presence of magnetic beads are studied for different coils as well as magnetic beads of different sizes and permeabilities. The simulation results are presented and discussed in order to obtain optimal coil parameters with the aim of producing maximum variations in the coil inductance.
DOI:10.1109/NEMS.2007.352072