Measuring and Mapping Optical Properties and Chromophore Changes During Brain Injury in the Near-Infrared Spectral Range Using Spatial Modulation of Light: Initial Results

In this paper we describe the use of spatially modulated light projection for quantifying changes in chromophores during acute ischemic injury in the rat barrel cortex. The approach we use is based on spatial modulation of white light projected onto the brain by commercial projector. The reflected l...

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Bibliographic Details
Main Authors: Abookasis, D., Mathews, M.S., Lay, C., Frostig, R.D., Linskey, M.E., Tromberg, B.J.
Format: Conference Proceeding
Language:English
Subjects:
Arteries
Biomedical imaging
Biomedical optical imaging
Brain injuries
Ischemic pain
Medical diagnostic imaging
Optical films
Optical imaging
Optical modulation
Optical saturation
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Summary:In this paper we describe the use of spatially modulated light projection for quantifying changes in chromophores during acute ischemic injury in the rat barrel cortex. The approach we use is based on spatial modulation of white light projected onto the brain by commercial projector. The reflected light is acquired on a CCD camera, which is then processed in the computer to obtain the concentration and distribution of chromophores through steady-state diffusion model. Experimental results from permanent stroke model underline the performance of the suggested techniques.
ISSN:1948-3546
1948-3554
DOI:10.1109/CNE.2007.369654