An in computo investigation of the Landau-Kleffner syndrome

We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epi...

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Bibliographic Details
Main Authors: Bonjean, M., Phillips, C., Thien Thanh Dang Vu, Sepulchre, R., Maquet, P.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical engineering
Brain modeling
Circuits
Computational modeling
Computer simulation
Cyclotrons
Electroencephalography
Epilepsy
Neurons
Surfaces
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Summary:We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies.
ISSN:1094-687X
1558-4615
DOI:10.1109/IEMBS.2007.4352893