Detection of Receptor-Ligand Interactions With an GHz Impedance Biosensor System

Nanogap impedance biosensors with an electrode separation of 75 nm have been used for the specific detection of biological interactions. Different model systems, such as thrombin-anti-thrombin antibody, and Rev-peptide-anti-Rev aptamer are presented to demonstrate the detectability of different mole...

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Bibliographic Details
Published in:IEEE sensors journal 2007-12, Vol.7 (12), p.1680-1684
Main Authors: Schlecht, U., Gronewold, T.M.A., Malave, A., Tewes, M.
Format: Article
Language:English
Subjects:
Acoustic signal detection
Antibodies
Biological interactions
Biosensor
Biosensors
Capacitors
Electrodes
Frequency
Impedance
interdigitated capacitors
Nanobioscience
Nanocomposites
nanogap
Nanomaterials
Nanostructure
Prostate cancer
prostate specific antigen (PSA)
Sensors
Signal to noise ratio
Surface impedance
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Summary:Nanogap impedance biosensors with an electrode separation of 75 nm have been used for the specific detection of biological interactions. Different model systems, such as thrombin-anti-thrombin antibody, and Rev-peptide-anti-Rev aptamer are presented to demonstrate the detectability of different molecular masses at varying concentrations. In order to improve the signal-to-noise ratio, the use of reference sensors has been explored. The interaction of prostate specific antigen (PSA) with an anti-PSA antibody is shown to demonstrate the detection at concentrations as low as 10 nM.
ISSN:1530-437X
1558-1748
DOI:10.1109/JSEN.2007.909230