High-Throughput Endpoint and Real-Time Detection of Biochemical Reactions in Microarrays Using Label-Free Oblique-Incidence Reflectivity Difference Microscopes

We describe recently developed oblique-incidence reflectivity difference microscopes, a form of polarization-modulated imaging ellipsometry, for label-free detection of biochemical reactions in microarrays. Configurations enabling high-throughput endpoint and real-time detection on glass substrates...

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Bibliographic Details
Main Authors: Landry, J.P., Sun, Y.S., Lam, K.S., Zhu, X.D.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical optical imaging
Dielectric substrates
Fluorescence
Glass
Microscopy
Molecular biophysics
Optical reflection
Optical surface waves
Proteins
Reflectivity
Online Access:Request full text
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Description
Summary:We describe recently developed oblique-incidence reflectivity difference microscopes, a form of polarization-modulated imaging ellipsometry, for label-free detection of biochemical reactions in microarrays. Configurations enabling high-throughput endpoint and real-time detection on glass substrates are discussed.
ISSN:2160-9004
DOI:10.1109/CLEO.2007.4453099