Cell Trapping in Activated Micropores for Functional Analysis

This paper presents a novel device which provides the opportunity to perform high-throughput biochemical assays on different individual cells. In particular, the proposed device is suited to screen the rare cells in biological samples for early stage cancer diagnosis and explore their biochemical fu...

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Bibliographic Details
Main Authors: Talasaz, A.A.H., Powell, A.A., Stahl, P., Ronaghi, M., Jeffrey, S.S., Mindrinos, M., Davis, R.W.
Format: Conference Proceeding
Language:English
Subjects:
Blood
Breast cancer
Breast neoplasms
Cells (biology)
Diseases
Functional analysis
Isolation technology
Medical treatment
Metastasis
Tumors
Online Access:Request full text
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Summary:This paper presents a novel device which provides the opportunity to perform high-throughput biochemical assays on different individual cells. In particular, the proposed device is suited to screen the rare cells in biological samples for early stage cancer diagnosis and explore their biochemical functionality. In the process, single cells are precisely positioned and captured in activated micropores. To show the performance of the proposed device, cultured yeast cells and human epithelial circulating tumor cells are successfully captured
ISSN:1557-170X
DOI:10.1109/IEMBS.2006.260233