Loading…

Accurate Localization of Brain Activity in Presurgical fMRI by Structure Adaptive Smoothing

An important problem of the analysis of functional magnetic resonance imaging (fMRI) experiments is to achieve some noise reduction of the data without blurring the shape of the activation areas. As a novel solution to this problem, recently the propagation-separation (PS) approach has been proposed...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on medical imaging 2008-04, Vol.27 (4), p.531-537
Main Authors: Tabelow, K., Polzehl, J., Ulug, A.M., Dyke, J.P., Watts, R., Heier, L.A., Voss, H.U.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An important problem of the analysis of functional magnetic resonance imaging (fMRI) experiments is to achieve some noise reduction of the data without blurring the shape of the activation areas. As a novel solution to this problem, recently the propagation-separation (PS) approach has been proposed. PS is a structure adaptive smoothing method that adapts to different shapes of activation areas. In this paper, we demonstrate how this method results in a more accurate localization of brain activity. First, it is shown in numerical simulations that PS is superior over Gaussian smoothing with respect to the accurate description of the shape of activation clusters and results in less false detections. Second, in a study of 37 presurgical planning cases we found that PS and Gaussian smoothing often yield different results, and we present examples showing aspects of the superiority of PS as applied to presurgical planning.
ISSN:0278-0062
1558-254X
DOI:10.1109/TMI.2007.908684