Magnetic solid lipid nanoparticles as mediators for controlled hyperthermia

This paper presents the development of magnetic lipid nanoparticles that could serve as targeting delivery vehicles and heat targeted cells in a desired manner. The nanoparticles are composed of lipid matrices with low melting temperatures and fabricated by high-pressure emulsification processes at...

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Bibliographic Details
Main Authors: Ming-Huang Hsu, Chung-Yu Liao, Yu-Chuan Su
Format: Conference Proceeding
Language:English
Subjects:
heating
Hyperthermia
Iron
iron oxide
Lipidomics
nanoparticle
Nanoparticles
Prototypes
Rough surfaces
Solids
Surface roughness
Temperature
Vehicles
Online Access:Request full text
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Summary:This paper presents the development of magnetic lipid nanoparticles that could serve as targeting delivery vehicles and heat targeted cells in a desired manner. The nanoparticles are composed of lipid matrices with low melting temperatures and fabricated by high-pressure emulsification processes at raised temperatures. Super-paramagnetic gamma-Fe 2 O 3 particles with sizes ranging from 5 to 25 nm are surface modified and dispersed evenly in the lipid nanoparticles. In the prototype demonstration, lipid nanoparticles with average sizes between 100 and 180 nm were fabricated. Meanwhile, roughly 40% to 65% of the dispersed iron oxide remained in the resulting lipid nanoparticles. When exposed to an alternating magnetic field of 60 kA/m at 25 kHz, a solution with 2 g/L encapsulated gamma-Fe 2 O 3 particles showed a temperature rise from 37 to 50degC in 20 minutes. As such, the presented solid lipid nanoparticles pioneer a new scheme of targeted and magnetically controlled hyperthermia, which is potentially applicable to a variety of medical treatments.
DOI:10.1109/NEMS.2008.4484443