Integrated flow sensing for focal biochemical stimulation

A microfluidic platform for focal stimulation of cells and tissue allows precise biochemical control of the extracellular microenvironment. This interface consists of a polymer microchannel having a single pore through which chemicals are selectively diffused or ejected. Towards the realization of r...

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Bibliographic Details
Main Authors: Li-Yuan Chang, Po-Ying Li, Lingyun Zhao, Tuan Hoang, Meng, E.
Format: Conference Proceeding
Language:English
Subjects:
Biosensors
Chemical and biological sensors
chemical stimulation
Extracellular
Feedback control
Fluid flow control
Microchannel
microfluidic delivery
Microfluidics
Monitoring
Parylene C
Polymers
thermal flow sensor
Thermal sensors
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Description
Summary:A microfluidic platform for focal stimulation of cells and tissue allows precise biochemical control of the extracellular microenvironment. This interface consists of a polymer microchannel having a single pore through which chemicals are selectively diffused or ejected. Towards the realization of realtime feedback control of focal biochemical stimulation, integrated thermal flow sensors were used to monitor fluid release. Delivery of fluorescent dye to rat retina is also presented.
DOI:10.1109/NEMS.2008.4484473