Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate

ZnO nanowires were grown on Ag wire with a diameter of ~250 mum and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1- 100 muM), the electrochemical res...

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Bibliographic Details
Published in:IEEE transactions on nanotechnology 2009-11, Vol.8 (6), p.678-683
Main Authors: Usman Ali, S.M., Nur, O., Willander, M., Danielsson, B.
Format: Article
Language:English
Subjects:
Biochemistry
Biochemistry and Molecular Biology
Biokemi och molekylärbiologi
Biologi
Biological and medical sciences
Biological Sciences
Biomedical transducers
biosensor
Biosensors
Biotechnology
Current measurement
electrochemical devices
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Gates
General equipment and techniques
Glucose
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Lead
Methods. Procedures. Technologies
MOSFET circuits
MOSFETs
Nanostructure
Nanowires
Natural Sciences
Naturvetenskap
Physics
Sensors
Sensors (chemical, optical, electrical, movement, gas, etc.)
remote sensing
Silver
Sugar
Various methods and equipments
Voltage measurement
Wire
Zinc oxide
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Summary:ZnO nanowires were grown on Ag wire with a diameter of ~250 mum and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1- 100 muM), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications.
ISSN:1536-125X
1941-0085
DOI:10.1109/TNANO.2009.2019958