Spatial organization of DNA: from the physical data to the 3D model

Behind its spatial organization, the DNA's molecule conceals a rich functional reality. As a result, the study of the DNA's organization is increasingly attracting scientists. However, researches conducted until now are either local, or global but based on approximations and predictions th...

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Bibliographic Details
Main Authors: Essabbah, M., Otmane, S., Mallem, M., Herisson, J.
Format: Conference Proceeding
Language:English
Subjects:
3D model
Bioinformatics
Biological cells
Biological system modeling
Biophysical data
Chromatin fibre
Compaction
Credible
DNA
Error analysis
Global
Laboratories
Predictive models
RNA
Stress
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Summary:Behind its spatial organization, the DNA's molecule conceals a rich functional reality. As a result, the study of the DNA's organization is increasingly attracting scientists. However, researches conducted until now are either local, or global but based on approximations and predictions that make the obtained model less credible. On the other hand, further researches on chromosomes' organization have identified some data and models representing, each one, a part of this organization. Our work aims to find a 3D repesentation that is global and more credible of the DNA's molecule. The molecule will be represented at the chromatin fiber level by means of 3D modeling algorithms. Initially, we have identified the biophysical data to be exploited. Indeed, we will first rely on the biophysical data of the chromatin fiber's structure as the persistence length along with the diameter, the confined volume and the curvature energy in order to build a first simple model of the chromatine.
ISSN:2161-5322
2161-5330
DOI:10.1109/AICCSA.2009.5069435