Validation of an automatic contour propagation method for lung cancer 4D adaptive radiation therapy

The objective of this work is to validate a fast and reliable 4D-based adaptive treatment planning procedure for the Radiation Oncology clinic. A non-rigid B-Spline based registration is performed between CT scans at different respiratory phases. Radiotherapy contours drawn on a reference phase are...

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Bibliographic Details
Main Authors: Peroni, M., Spadea, M.F., Riboldi, M., Baroni, G., Chen, G.T.Y., Sharp, G.C.
Format: Conference Proceeding
Language:English
Subjects:
4D Treatment Planning
Adaptive Radiation Therapy
Anthropomorphism
Biomedical applications of radiation
Cancer
Computed tomography
Contour Propagation
Deformable Registration
Imaging phantoms
Lesions
Lungs
Medical treatment
Oncology
Re-planning
Spline
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Summary:The objective of this work is to validate a fast and reliable 4D-based adaptive treatment planning procedure for the Radiation Oncology clinic. A non-rigid B-Spline based registration is performed between CT scans at different respiratory phases. Radiotherapy contours drawn on a reference phase are than propagated to the target phase. We present results from two novel validation methods: a validation study using a 4D anthropomorphic computational phantom, and a patient data analysis comparing auto-rater versus inter-rater variability. For the phantom study, the overlap was greater than 90%, while the diameter variation was 5.1% at exhale and 3.4% at inhale. For the patient dataset, pairwise auto-rater Dice coefficient values exceeded inter-rater values for 9 of 15 structures. Though subject to inaccuracies caused by residual motion artifacts, and manual contouring variations, the reliability of the method suggests it could be soon introduced in the clinical practice.
ISSN:1945-7928
1945-8452
DOI:10.1109/ISBI.2009.5193241