Automated reconstruction of the cerebral cortex in multiple sclerosis patients

Although cortical atrophy in multiple sclerosis (MS) has been reported in the literature, most cortical reconstruction techniques do not account for lesions. In this work, we propose an automated pipeline for cortical reconstruction from magnetic resonance brain images with MS lesions. The pipeline...

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Bibliographic Details
Main Authors: Shiee, N., Bazin, P.-L., Reich, D.S., Pham, D.L.
Format: Conference Proceeding
Language:English
Subjects:
Atrophy
Brain modeling
Cerebral cortex
Cortical reconstruction
Cortical thickness
Image reconstruction
Lesion segmentation
Lesions
Magnetic resonance
Magnetic resonance imaging
Multiple sclerosis
Pipelines
Thickness measurement
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Description
Summary:Although cortical atrophy in multiple sclerosis (MS) has been reported in the literature, most cortical reconstruction techniques do not account for lesions. In this work, we propose an automated pipeline for cortical reconstruction from magnetic resonance brain images with MS lesions. The pipeline extends previously well validated methods to allow for the presence of lesions and to accommodate multichannel imaging. We validate this approach on simulated and real images. Application of the pipeline to 103 MS brains produces thickness measurements that agree well with the literature.
ISSN:1945-7928
1945-8452
DOI:10.1109/ISBI.2009.5193311