Identifying Candidate Cancer Genes Based on Their Somatic Mutations Co-Occurring with Cancer Genes in Cancer Genome Profiling

After decades of searching, only 10-20% of all cancer genes are known. Identifying candidate cancer genes are still a central aim of cancer research. In current high throughput studies of screening somatic mutations in cancer genome, only genes mutated more frequently than what would be expected by...

Full description

Saved in:
Bibliographic Details
Main Authors: Jing Zhu, Xiaopei Shen, Yang Zhang, Zheng Guo, Hui Xiao, Yunyan Gu
Format: Conference Proceeding
Language:English
Subjects:
Bioinformatics
Cancer
Educational institutions
Frequency
Genetic mutations
Genomics
Humans
Neoplasms
Throughput
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:After decades of searching, only 10-20% of all cancer genes are known. Identifying candidate cancer genes are still a central aim of cancer research. In current high throughput studies of screening somatic mutations in cancer genome, only genes mutated more frequently than what would be expected by chance are determined as candidate cancer genes. However, mutations of multiple genes participating in different pathways are suggested to be synergistic in conferring selection advantages to the tumor. Here, considering the cooperation of multiple cancer genes during tumorigenesis, we identified 23 candidate cancer genes co-mutated with known cancer genes in the same cancer samples significantly more frequently than expected by random chance. The potential roles of these candidate cancer genes in tumorigenesis are strongly supported by literatures.
ISSN:1948-2914
1948-2922
DOI:10.1109/BMEI.2009.5304750