Potential and Challenges for Mid-Infrared Sensors in Breath Diagnostics

Exhaled breath contains more than 1000 constituents at trace level concentrations, with a wide variety of these compounds potentially serving as biomarkers for specific diseases, physiologic status, or therapeutic progress. Some of the compounds in exhaled breath (EB) are well studied, and their rel...

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Bibliographic Details
Published in:IEEE sensors journal 2010-01, Vol.10 (1), p.145-158
Main Authors: Seong-Soo Kim, Young, C., Vidakovic, B., Gabram-Mendola, S., Bayer, C.W., Mizaikoff, B.
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Biomarkers
Biomedical monitoring
Biomedical optical imaging
Biosensors
breast cancer
chemical sensor
Costs
Diseases
exhaled breath (EB)
exhaled breath condensate (EBC)
exposure monitoring
hollow waveguide
infrared sensor
mid-infrared (MIR)
optical sensor
Optical sensors
Optical waveguides
Pathology
planar waveguide
quantum cascade laser
Spectroscopy
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Summary:Exhaled breath contains more than 1000 constituents at trace level concentrations, with a wide variety of these compounds potentially serving as biomarkers for specific diseases, physiologic status, or therapeutic progress. Some of the compounds in exhaled breath (EB) are well studied, and their relationship with disease pathologies is well established. However, molecularly specific analysis of such biomarkers in EB at clinically relevant levels remains an analytical and practical challenge due to the low levels of such biomarkers frequently below the ppb (v/v) range in EB. In this contribution, mid-infrared (MIR) spectroscopic sensing techniques are reviewed for potential application in breath diagnostics. While the spectral regime from 3-20 ¿m has already been utilized for fundamental studies on breath analysis, significant further improvements are in demand for substantiating MIR spectroscopy and sensing techniques as a suitable candidate for clinically deployable breath analyzers. Several advantageous features including inherent molecular selectivity, real-time monitoring capability, comparable ease of operation, potentially low costs, and a compact device footprint promise reliable optical diagnostics in the MIR. Hence, while the application of MIR spectroscopy and sensing systems to breath analysis yet appear in their infancy, recent progress on advanced MIR light sources, waveguides, and device concepts forecasts next-generation optical sensing platforms suitable for addressing the challenges of in situ breath diagnostics.
ISSN:1530-437X
1558-1748
DOI:10.1109/JSEN.2009.2033940