Degradation related cytotoxicity of quantum dots

Before using semiconductor quantum dots (QDs) in biomedical applications in vivo, it's important to know about their interaction with biological surroundings, stability in living organisms, intracellular distribution and cytotoxicity. We have investigated CdTe-MPA and (CdSe)ZnS-MUA QDs in the o...

Full description

Saved in:
Bibliographic Details
Main Authors: Karabanovas, V., Rotomskis, R., Beganskiene, A., Kareiva, A., Bagdonas, S., Grigaravicius, P., Greulich, K.O.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical imaging
Cells (biology)
Chemistry
cytotoxicity
Degradation
In vivo
Nanoparticles
Photoluminescence
Physics
Quantum dots
Stability
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 457
container_issue
container_start_page 454
container_title
container_volume
creator Karabanovas, V.
Rotomskis, R.
Beganskiene, A.
Kareiva, A.
Bagdonas, S.
Grigaravicius, P.
Greulich, K.O.
description Before using semiconductor quantum dots (QDs) in biomedical applications in vivo, it's important to know about their interaction with biological surroundings, stability in living organisms, intracellular distribution and cytotoxicity. We have investigated CdTe-MPA and (CdSe)ZnS-MUA QDs in the osteosarcoma U2-OS cell culture. The changes in photoluminescence spectra of QDs, the localization of QDs in living cells and the influence on the cell viability were studied. We have found that spectra of CdTe - MPA QDs became blue-shifted in the incubation medium and U2-OS cancer cells, which were incubated with these QDs, were inactivated after 24 h. This notable shift from 631 nm to 614 nm implies that QDs degraded releasing Cd 2+ ions, known to be cytotoxic. On the other hand, the spectra of (CdSe)ZnS-MUA QDs didn't change and accumulation of these QDs in cells had no impact on their viability after 24 h.
format conference_proceeding
fullrecord <record><control><sourceid>ieee_CHZPO</sourceid><recordid>TN_cdi_ieee_primary_5394708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ieee_id>5394708</ieee_id><sourcerecordid>5394708</sourcerecordid><originalsourceid>FETCH-ieee_primary_53947083</originalsourceid><addsrcrecordid>eNp9zrsOgjAUgOF6SwT1CVz6AiS9HKSdvcQHcCcNFFIDVNtDIm-vg3F0-odv-Wck1YozJQ8a8jlJuAbItFRsQVIOAgCUFGr5A63XJI3xzphgouAJYSfbBlMbdH6gwXYGbU2rCT36l6scTtQ39DmaAcee1h7jlqwa00W7-3ZD9pfz7XjNnLW2fATXmzCVudRQfLb-6xsqFTNj</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype></control><display><type>conference_proceeding</type><title>Degradation related cytotoxicity of quantum dots</title><source>IEEE Xplore All Conference Series</source><creator>Karabanovas, V. ; Rotomskis, R. ; Beganskiene, A. ; Kareiva, A. ; Bagdonas, S. ; Grigaravicius, P. ; Greulich, K.O.</creator><creatorcontrib>Karabanovas, V. ; Rotomskis, R. ; Beganskiene, A. ; Kareiva, A. ; Bagdonas, S. ; Grigaravicius, P. ; Greulich, K.O.</creatorcontrib><description>Before using semiconductor quantum dots (QDs) in biomedical applications in vivo, it's important to know about their interaction with biological surroundings, stability in living organisms, intracellular distribution and cytotoxicity. We have investigated CdTe-MPA and (CdSe)ZnS-MUA QDs in the osteosarcoma U2-OS cell culture. The changes in photoluminescence spectra of QDs, the localization of QDs in living cells and the influence on the cell viability were studied. We have found that spectra of CdTe - MPA QDs became blue-shifted in the incubation medium and U2-OS cancer cells, which were incubated with these QDs, were inactivated after 24 h. This notable shift from 631 nm to 614 nm implies that QDs degraded releasing Cd 2+ ions, known to be cytotoxic. On the other hand, the spectra of (CdSe)ZnS-MUA QDs didn't change and accumulation of these QDs in cells had no impact on their viability after 24 h.</description><identifier>ISSN: 1944-9399</identifier><identifier>ISBN: 1424448328</identifier><identifier>ISBN: 9781424448326</identifier><identifier>EISSN: 1944-9380</identifier><identifier>EISBN: 9810836945</identifier><identifier>EISBN: 9789810836948</identifier><language>eng</language><publisher>IEEE</publisher><subject>Biomedical imaging ; Cells (biology) ; Chemistry ; cytotoxicity ; Degradation ; In vivo ; Nanoparticles ; Photoluminescence ; Physics ; Quantum dots ; Stability</subject><ispartof>2009 9th IEEE Conference on Nanotechnology (IEEE-NANO), 2009, p.454-457</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/5394708$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>309,310,780,784,789,790,2058,54555,54920,54932</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/5394708$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Karabanovas, V.</creatorcontrib><creatorcontrib>Rotomskis, R.</creatorcontrib><creatorcontrib>Beganskiene, A.</creatorcontrib><creatorcontrib>Kareiva, A.</creatorcontrib><creatorcontrib>Bagdonas, S.</creatorcontrib><creatorcontrib>Grigaravicius, P.</creatorcontrib><creatorcontrib>Greulich, K.O.</creatorcontrib><title>Degradation related cytotoxicity of quantum dots</title><title>2009 9th IEEE Conference on Nanotechnology (IEEE-NANO)</title><addtitle>NANO</addtitle><description>Before using semiconductor quantum dots (QDs) in biomedical applications in vivo, it's important to know about their interaction with biological surroundings, stability in living organisms, intracellular distribution and cytotoxicity. We have investigated CdTe-MPA and (CdSe)ZnS-MUA QDs in the osteosarcoma U2-OS cell culture. The changes in photoluminescence spectra of QDs, the localization of QDs in living cells and the influence on the cell viability were studied. We have found that spectra of CdTe - MPA QDs became blue-shifted in the incubation medium and U2-OS cancer cells, which were incubated with these QDs, were inactivated after 24 h. This notable shift from 631 nm to 614 nm implies that QDs degraded releasing Cd 2+ ions, known to be cytotoxic. On the other hand, the spectra of (CdSe)ZnS-MUA QDs didn't change and accumulation of these QDs in cells had no impact on their viability after 24 h.</description><subject>Biomedical imaging</subject><subject>Cells (biology)</subject><subject>Chemistry</subject><subject>cytotoxicity</subject><subject>Degradation</subject><subject>In vivo</subject><subject>Nanoparticles</subject><subject>Photoluminescence</subject><subject>Physics</subject><subject>Quantum dots</subject><subject>Stability</subject><issn>1944-9399</issn><issn>1944-9380</issn><isbn>1424448328</isbn><isbn>9781424448326</isbn><isbn>9810836945</isbn><isbn>9789810836948</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2009</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><recordid>eNp9zrsOgjAUgOF6SwT1CVz6AiS9HKSdvcQHcCcNFFIDVNtDIm-vg3F0-odv-Wck1YozJQ8a8jlJuAbItFRsQVIOAgCUFGr5A63XJI3xzphgouAJYSfbBlMbdH6gwXYGbU2rCT36l6scTtQ39DmaAcee1h7jlqwa00W7-3ZD9pfz7XjNnLW2fATXmzCVudRQfLb-6xsqFTNj</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Karabanovas, V.</creator><creator>Rotomskis, R.</creator><creator>Beganskiene, A.</creator><creator>Kareiva, A.</creator><creator>Bagdonas, S.</creator><creator>Grigaravicius, P.</creator><creator>Greulich, K.O.</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope></search><sort><creationdate>200907</creationdate><title>Degradation related cytotoxicity of quantum dots</title><author>Karabanovas, V. ; Rotomskis, R. ; Beganskiene, A. ; Kareiva, A. ; Bagdonas, S. ; Grigaravicius, P. ; Greulich, K.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ieee_primary_53947083</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biomedical imaging</topic><topic>Cells (biology)</topic><topic>Chemistry</topic><topic>cytotoxicity</topic><topic>Degradation</topic><topic>In vivo</topic><topic>Nanoparticles</topic><topic>Photoluminescence</topic><topic>Physics</topic><topic>Quantum dots</topic><topic>Stability</topic><toplevel>online_resources</toplevel><creatorcontrib>Karabanovas, V.</creatorcontrib><creatorcontrib>Rotomskis, R.</creatorcontrib><creatorcontrib>Beganskiene, A.</creatorcontrib><creatorcontrib>Kareiva, A.</creatorcontrib><creatorcontrib>Bagdonas, S.</creatorcontrib><creatorcontrib>Grigaravicius, P.</creatorcontrib><creatorcontrib>Greulich, K.O.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Xplore</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Karabanovas, V.</au><au>Rotomskis, R.</au><au>Beganskiene, A.</au><au>Kareiva, A.</au><au>Bagdonas, S.</au><au>Grigaravicius, P.</au><au>Greulich, K.O.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Degradation related cytotoxicity of quantum dots</atitle><btitle>2009 9th IEEE Conference on Nanotechnology (IEEE-NANO)</btitle><stitle>NANO</stitle><date>2009-07</date><risdate>2009</risdate><spage>454</spage><epage>457</epage><pages>454-457</pages><issn>1944-9399</issn><eissn>1944-9380</eissn><isbn>1424448328</isbn><isbn>9781424448326</isbn><eisbn>9810836945</eisbn><eisbn>9789810836948</eisbn><abstract>Before using semiconductor quantum dots (QDs) in biomedical applications in vivo, it's important to know about their interaction with biological surroundings, stability in living organisms, intracellular distribution and cytotoxicity. We have investigated CdTe-MPA and (CdSe)ZnS-MUA QDs in the osteosarcoma U2-OS cell culture. The changes in photoluminescence spectra of QDs, the localization of QDs in living cells and the influence on the cell viability were studied. We have found that spectra of CdTe - MPA QDs became blue-shifted in the incubation medium and U2-OS cancer cells, which were incubated with these QDs, were inactivated after 24 h. This notable shift from 631 nm to 614 nm implies that QDs degraded releasing Cd 2+ ions, known to be cytotoxic. On the other hand, the spectra of (CdSe)ZnS-MUA QDs didn't change and accumulation of these QDs in cells had no impact on their viability after 24 h.</abstract><pub>IEEE</pub></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 1944-9399
ispartof 2009 9th IEEE Conference on Nanotechnology (IEEE-NANO), 2009, p.454-457
issn 1944-9399
1944-9380
language eng
recordid cdi_ieee_primary_5394708
source IEEE Xplore All Conference Series
subjects Biomedical imaging
Cells (biology)
Chemistry
cytotoxicity
Degradation
In vivo
Nanoparticles
Photoluminescence
Physics
Quantum dots
Stability
title Degradation related cytotoxicity of quantum dots
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T01%3A44%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-ieee_CHZPO&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=proceeding&rft.atitle=Degradation%20related%20cytotoxicity%20of%20quantum%20dots&rft.btitle=2009%209th%20IEEE%20Conference%20on%20Nanotechnology%20(IEEE-NANO)&rft.au=Karabanovas,%20V.&rft.date=2009-07&rft.spage=454&rft.epage=457&rft.pages=454-457&rft.issn=1944-9399&rft.eissn=1944-9380&rft.isbn=1424448328&rft.isbn_list=9781424448326&rft_id=info:doi/&rft.eisbn=9810836945&rft.eisbn_list=9789810836948&rft_dat=%3Cieee_CHZPO%3E5394708%3C/ieee_CHZPO%3E%3Cgrp_id%3Ecdi_FETCH-ieee_primary_53947083%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_ieee_id=5394708&rfr_iscdi=true