Simple correction of chemical shift changes in magnetic resonance spectroscopy quantitation

High-resolution magic angle spinning (HRMAS) 1 H spectroscopy is playing an increasingly important role for diagnosis. This technique enables setting up metabolite profiles of ex vivo pathological and healthy tissue. Automatic quantitation of HRMAS signals provides reliable reference profiles to mon...

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Bibliographic Details
Main Authors: Lazariev, A, Piotto, M, Elbayed, K, Namer, I J, van Ormondt, D, Graveron-Demilly, D
Format: Conference Proceeding
Language:English
Subjects:
Chemicals
Computerized monitoring
Diseases
HRMAS
jMRUI Software Package
Magnetic resonance
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Pathology
Pharmaceuticals
Quantitation
Sampling methods
Spectroscopy
Spinning
Stretching
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Summary:High-resolution magic angle spinning (HRMAS) 1 H spectroscopy is playing an increasingly important role for diagnosis. This technique enables setting up metabolite profiles of ex vivo pathological and healthy tissue. Automatic quantitation of HRMAS signals provides reliable reference profiles to monitor diseases and pharmaceutical follow-up. Nevertheless, for several metabolites chemical shifts may slightly differ according to the micro-environment in the tissue or cells, in particular its pH. This hampers accurate estimation of the metabolite concentrations mainly when using quantitation algorithms based on a metabolite basis-set. In this work, we propose a user-friendly way to circumvent this problem based on stretching of the metabolite basis-set signals and maximization of the correlation between the HRMAS and basis-set spectra prior to quantitation.
ISSN:1558-2809
2832-4242
DOI:10.1109/IST.2010.5548476