A Model of Intelligent Controller for Hypothyroidism Treatment

Hypothyroidism results from an insufficiency either in the production or/and in the action of the thyroid hormones. Most of the patients in hypothyroidism state must adopt hormonal replacement therapy for all their lives. An intelligent controller model for supplying therapeutic drugs to primary hyp...

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Bibliographic Details
Main Authors: Martins, Luiz G A, Monteiro, Luiz H A
Format: Conference Proceeding
Language:English
Subjects:
Artificial neural networks
Biochemistry
Drugs
Glands
Intelligent control
Maintenance engineering
Mathematical model
neural networks
Production
production rules
thyroid hormones
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Summary:Hypothyroidism results from an insufficiency either in the production or/and in the action of the thyroid hormones. Most of the patients in hypothyroidism state must adopt hormonal replacement therapy for all their lives. An intelligent controller model for supplying therapeutic drugs to primary hypothyroidism patients, without the thyroid gland, is investigated in this work. Two multilayer perceptron neural networks are used to predict the concentrations of the hormones TSH and T4 in the blood. The controller, based on a set of production rules, uses these forecasts and the current concentrations of such hormones for calculating the necessary drug dosage to be released. Beyond the controller maintaining such concentrations inside regularity bands, it is also able of preventing abrupt changes on the time evolution of these concentrations.
DOI:10.1109/CIT.2010.106