Tailoring the drug loading capacity of polypyrrole films for use in intraocular biomicrorobots

Preliminary results concerning impregnation of polypyrrole (Ppy) films with rhodamine B (Rh-B) are presented. The films are envisioned to be functional surface coatings on biomicrorobots for controlled drug delivery. The polypyrrole films were obtained on gold substrates by anodic oxidation of pyrro...

Full description

Saved in:
Bibliographic Details
Published in:2010 Annual International Conference of the IEEE Engineering in Medicine and Biology 2010-01, p.4359-4362
Main Authors: Sivaraman, K M, Bayrakceken, K, Ergeneman, O, Pané, S, Lühmann, T, Hall, H, Nelson, B J
Format: Article
Language:English
Subjects:
Drugs
Integrated circuits
Rough surfaces
Surface roughness
Surface treatment
Citations: Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preliminary results concerning impregnation of polypyrrole (Ppy) films with rhodamine B (Rh-B) are presented. The films are envisioned to be functional surface coatings on biomicrorobots for controlled drug delivery. The polypyrrole films were obtained on gold substrates by anodic oxidation of pyrrole in aqueous solutions containing sodium dodecylbenzenesulfonate (SDBS) as doping agent. The influence of the sodium doping level on the wettability of the Ppy surfaces, and the loading capacity of Rh-B is systematically analyzed. The undoping of the films results in the formation of surface microcracks and tends to make the surface hydrophobic in nature, which subsequently leads to an increase of the adsorption capacity of Rh-B on the Ppy deposit. This controllable increase in adsorption capacity provides an opportunity to tailor the drug loading capacity of Ppy films.
ISSN:1094-687X
1558-4615
DOI:10.1109/IEMBS.2010.5627112