Metabolite absolute quantification in rabbit liver by proton magnetic resonance spectroscopy

MRS enables the noninvasive measurement of metabolic concentration in vivo. However, to our knowledge, the study of quantification of liver metabolites by magnetic resonance spectroscopy in clinic MR scanner is very little. In this paper, we have quantitative analyzed liver metabolites with the exte...

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Bibliographic Details
Main Authors: Zhiwei Shen, Kezeng You, Zhongxian Yang, Yaowen Chen, Renhua Wu
Format: Conference Proceeding
Language:English
Subjects:
Absolute Quantification
In vivo
LCModel
Lipidomics
Liver
Magnetic resonance spectroscopy
Phantoms
Protons
Rabbits
Spectroscopy
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Summary:MRS enables the noninvasive measurement of metabolic concentration in vivo. However, to our knowledge, the study of quantification of liver metabolites by magnetic resonance spectroscopy in clinic MR scanner is very little. In this paper, we have quantitative analyzed liver metabolites with the external phantom replacement method and LCModel software. To demonstrate its feasibility, we applied the technique to ten rabbits. Ten single-voxel proton spectra of liver were acquired at 1.5T using the 8 channel head/neck receive coil. The absolute concentration of choline-containing compounds (Cho), liquid (LL) and glycogen (Glyu) in rabbit livers in vivo was estimated. By comparing the mean value and SD of these metabolites with previous studies, we think that the proposed method is accurate and may be a promising technique with clinical value.
ISSN:1948-2914
1948-2922
DOI:10.1109/BMEI.2010.5640054