An electrical DNA sensor with gold decorated SWCNT network

We report a novel electrical DNA biosensor, which consists of gold (Au) nano islands and SWCNT net on top of a semi-concentric Au electrode array (also referred to as the CGi). The real time measurement in TE buffer solution in a wide range of the target ss-DNA concentration down to fM (10 -15 M) wa...

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Bibliographic Details
Main Authors: Jung Woo Ko, Jin-Hong Ahn, Jim Ho Cheon, Tae June Kang, Yong Hyup Kim, Young June Park
Format: Conference Proceeding
Language:English
Online Access:Request full text
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Summary:We report a novel electrical DNA biosensor, which consists of gold (Au) nano islands and SWCNT net on top of a semi-concentric Au electrode array (also referred to as the CGi). The real time measurement in TE buffer solution in a wide range of the target ss-DNA concentration down to fM (10 -15 M) was performed to check the detection limit. The CGi, functionalized with 25mer probe ss-DNA (5'-HSC 6 -C 18 -GC CAT TCT CAC CGH ATT CAG TCG TC-3') shows high binding affinity of complementary ss-DNA targets until 10 -13 M. Moreover, it differentiates the mismatched target ss-DNA with high selectivity. This kind of CGi sensor platform can be applied to a target specific biological recognition element such as aptamer and protein easily, thereby realizing a general sensor platform for sensing many different types of biomolecules.
ISSN:1944-9399
1944-9380
DOI:10.1109/NANO.2010.5698029